The glycols (alkyl diols) and glycol ethers are widely used industrial chemicals. More recent toxicogenomics work with MAA has found significant response of oxidative stress responsive genes, which leads into our next proposal for considering mechanisms. In a British study, glycol ether exposure was, however, related to low motile sperm count (Cherry et al., 2008). We use cookies to help provide and enhance our service and tailor content and ads. This elasticity provides clinical advantages because it allows substantial swelling without cutting into tissue and maintains tissue approximation throughout healing. 0 Unambiguous epidemiological studies investigating the potential developmental toxicity of these compounds are lacking and thus our knowledge of their developmental effects is based primarily on animal studies. Wang, in Encyclopedia of Toxicology (Third Edition), 2014. [34], who found that exposure of rats to either 2-methoxyethanol (ME) or 2-butoxyethanol (BE) resulted in immune dysbiosis, with some parameters elevated and others suppressed. 2 These chemicals are generally valued for their low acute toxicity. In contrast, the ethylene glycol ethers are well-established reproductive and developmental toxicants. Ge (group 1 and 2) are experimentally toxic for reproduction and development, at various levels. The preceding section described the clinical features of ethylene glycol poisoning in three stages that are based on the time after ingestion. Exposure to glycol ethers (in particular, 2-methoxyethanol and 2-ethoxyethanol) has been related to reduced semen quality in shipyard painters, metal casters, chemical industry workers and semiconductor industry workers (Figá-Talamanca et al., 2001). Health effects of glycol ethers reviewed. Standard toxicity studies cond … The authors conclude that low exposure to most toxic glycol ethers still appears to be widespread and thus these agents continue to be a workplace hazard. They are absorbed as volatile fumes from the air by the skin as well as inhalation. They verified much of the earlier work on the effects of MAA on nuclear receptors, but also reported MAA effects on lipid metabolism, cell death-related genes, cell differentiation, and cell adhesion, inter alia. describe the physiologic effects of ethylene glycol poisoning. An update on toxicity studies of glycol ethers to Apr. Alkoxyethanols are mainly eliminated as alkoxyacetic acid via urine. 1 A new study in Environmental Health Perspectives provides some of the first evidence of associations between prenatal exposures to glycol ethers and cognitive impairments in children. Restricted ACGIH lowered TLVs for EGME, EGMEA, EGEE, and EGEEA in 1985 to 5 ppm after new animal evidence … Rodent studies investigating the developmental toxicity of ethylene glycol (EG) have indicated developmental toxicity but only at exceptionally high doses, at or above 1000 mg kg−1 day−1 (ATSDR, 2010). The fact that such gene sets were upregulated in a transformed line of a cell type which shows no pathology or visible change after EGME exposure in vivo is perplexing. A current model of 2-BE effects seen in mice suggests that 2-BE induces macrophage activation and inflammation in the liver involving Kupffer cells (liver macrophages). Glycol ethers (Ge) are a family of substances with a growing use in industrial and domestic products for the two last decades. Glycol Ethers Causes reproductive effects . !�2�KY!2��F&{dг���B+�Y����̡s�. moderate . Glycol ethers and their acetates are used in a variety of industries and products. Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. In a multicenter case–control study, maternal glycol ether exposure was associated with congenital malformations (Cordier et al., 1997). Environmental Health Perspectives Vol. Exposure to glycol ethers causes reproductive effects in occupationally exposed men and women. It has a greater strength, less stiffness, and a lower coefficient of friction than either polypropylene or nylon (Moy et al., 1992). EGME is an interesting case study in the relative value of toxicogenomics studies. Methoxyethanol is an E-series glycol ether derived from methanol and ethylene oxide. 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